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KMID : 0545120060160101656
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Journal of Microbiology and Biotechnology
2006 Volume.16 No. 10 p.1656 ~ p.1659
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A Comparison of the Anti-inflammatory Activity of Surfactin A, B, C, and D from Bacillus subtilis
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Kim Sung-Dae
Cho Jae-Youl
Park Hwa-Jin
Im Chang-Ryul
Lim Jong-Hwan
Yun Hyo-In
Park Seung-Chun
Kim Sang-Keun
Rhee Man-Hee
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Abstract
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Natural surfactins are a mixture of isoforms that differ slightly in their physiological properties. In previous research, we obtained surfactin A, B, C, and D from the Bacillus subtilis complex BC1212. We found that surfactin C inhibited nitric oxide (NO)-production and suppressed the expression of pro-inflammatory cytokine mRNA, which was stimulated by of lipopolysaccharide (LPS) in murine RAW264.7 cells. In order to compare the anti-inflammatory effects of surf actin isoforms, we examined the inhibition of LPS-induced NO production and the pro-inflammatory cytokine expression level. Surfactin C inhibited the LPS-induced NO production in murine macrophage RAW264.7 cells the most. In addition, surf actin C was superior to other surfactin's subtypes regarding inhibiting the expression of inducible nitric oxide synthase (iNOS) and monocyte chemoattractant protein 1 (MCP-1). Finally, the anti-inflammatory activity of surf actin C is the most potent, compared with surfactin A, B, and D.
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KEYWORD
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Surfactin A, B, C, D, anti-inflammatory activity, nitric oxide, inducible nitric oxide synthase, pro-inflammatory cytokines
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